Tingling in hands and feet, often associated with loss of motivation or depressive mood.

Occurs early - shooting, burning pain in the arms and legs, triggered or intensified by exertion, fever or stress.

Small, reddish-bluish skin spots between the navel and knees, often in the pubic area.

Disturbed sweat regulation - heat and exertion often lead to nausea, drowsiness, headaches or fainting.

Kidneys often severely affected - deposits can quickly lead to kidney failure, usually resulting in dialysis or transplantation.

Thickening of the left ventricle, shortness of breath on exertion and increased risk of angina pectoris, heart attack or stroke.